Cell based models

Small molecules, immunotherapy, cell therapy, and other treatment options are optimized using in vitro or ex vivo models and analyzed by various flow cytometry functional assays. Celleqore functional assays are an excellent measure of treatment performance on direct cell types within a given indication and provide critical data used to select appropriate in vivo efficacy models.

In vitro

In vivo

Tumor Model 1

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Flow cytometry functional assay showing tumor model 1 out of 6 treated in vitro with therapeutic agents (T1,T2,T3,T4). The outcome of the functional assay study predicted tumor model 1 treated with combination T1+T2+T4 in vitro (top) would be efficacious in vivo (bottom).

In vitro

In vivo

Tumor Model 2

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Flow cytometry functional assay showing tumor model 2 out of 6 treated in vitro with therapeutic agents (T1,T2,T3,T4). The outcome of the functional assay study predicted tumor model 2 treated with combination T1+T2 in vitro (top) would be non-efficacious in vivo (bottom).